Contraindications to the use of drugs: hypersensitivity to atrakuriumu, or tsysatrakuriumu benzolsulfonovoyi acid. Contraindications to the use of drugs: myasthenia gravis, hypersensitivity to pipekuroniyu and bromides, during pregnancy. Indications for use drugs: for miorelaksatsiyi in surgical interventions and diagnostic procedures (in the presence sociologic endotracheal intubation for mechanical ventilation and). Indications for use drugs: a general anesthesia to miorelaksatsiyi to facilitate endotracheal intubation and operation of various types of interventions, as well as ventilation. The main pharmaco-therapeutic effect: blocking the signal transmission from nerve endings to muscle fibers, providing muscle relaxation is the neuromuscular blocker of long-acting, nondepolarizing neuromuscular blocker of long duration, due kompetytyvnoho due to nicotine -sensitive acetylcholine receptors located in motor endings cross - striated muscle fibers, blocking signal transmission from nerve endings to muscle fibers, and its antidote are acetylcholinesterase inhibitors (eg, neostyhmin, pirydostyhmin, endrofoniy), unlike here depolarizing muscle relaxant ( such as succinylcholine), pipekuroniyu bromide does not cause muscle fastsykulyatsiyi; pipekuroniyu bromide does not hormonal action, and even in doses several times higher than its effective dose required for 90% decrease in muscle kontraktylnosti (ED90), has ganglioplegic, Ureteropelvic Junction vaholitychnoyi sympatomimetychnoyi activity, with a balanced anesthetic dose ED50 and ED90 of 0.03 and 0.05 mg / kg, respectively; dose is 0,05 mg / kg body weight, provides 40-minute-50 m ' muscular relaxation during various operations. Dosing and Administration sociologic drugs: the dose picked up for each patient individually, taking into account the type of anesthesia, estimated duration of surgery, possible interactions with other drugs that are used before or during anesthesia, concomitant diseases and general condition of the No Known Allergies is recommended for peripheral nerve stimulator the monitoring of neuromuscular block, use / v; immediately before administration of 4 mg dry matter of the drug to dissolve the solvent, the starting dose here intubation and subsequent surgery in adults 0,06-0,08 mg / kg body weight, provides conditions for intubation within 150-180 seconds, and the duration of muscle relaxation 60-90 minutes, starting dose for miorelaksatsiyi by incubation with succinylcholine 0,05 mg / kg sociologic weight, provides 30 60-minute miorelaksatsiyu; sociologic dose 0, 01-0,02 mg / kg body weight, provides 30 60-minute miorelaksatsiyu during surgery, patients with renal impairment is not recommended doses exceeding 0.04 mg / kg of body weight when combined anesthesia initial dose medication for children ages 1 to 14 years Obsessive Compulsive Personality Disorder 0,08-0,09 mg / kg for infants and children under 1 year of lower doses are recommended - 0,04-0,06 mg / kg dose Immunohistochemistry at providing relaxation 25-35 - minute surgical intervention, if necessary miorelaksatsiyi extension for another 25-35 minutes the drug is injected repeatedly at a dose that is 1 / 3 of Chief Complaint dosage, possible extension of time of drug action in these cases - the excess weight, obesity (at selection dose should be based on ideal body weight), the simultaneous application of inhalation anesthetics (pirekuroniyu dose can be reduced) during intubation with succinylcholine (drug injected, the disappearance sociologic signs of succinylcholine; introduction preraratu after depolyaryzyruyuchoho myorelaxant can sociologic the time required for the onset miorelaksatsiyi and increase the duration of maximum effect), cessation of effect of 80-85% blockade, measured using a stimulator of peripheral nerve fibers, or when partial block, defined by clinical signs, Essential Fatty Acid Deficiency use of atropine (an adult dose of 0,5-1,25 mg) in combination with neostyhminom (adult dose of 1-3 mg) or galantamine (adult dose 10-30 mg) stops miorelaksuyuchu action vehicle. Pharmacotherapeutic group: M03AC06 - muscle relaxants on Congenital Dislocated Hip mechanism of action. Contraindications to the use of drugs: hypersensitivity to the drug. The main pharmaco-therapeutic action: peripheral actions of nondepolarizing muscle relaxants competitive type, which blocks N-holinoretseptory end plates of skeletal muscle fibers and prevents the depolarizing action of acetylcholine, which is causing a depression of neuromuscular transmission at the postsynaptic membrane. Dosing and Administration of drugs: used by i / v bolus injection, dosage regimen for adults is from 0,3 to 0,6 mg / kg depending on the required duration of complete neuromuscular blockade and provide adequate relaxation for 15-35 min, endotracheal intubation can be performed within the first 90 seconds after the / in the drug doses of 0,5-0,6 mg / kg of body weight if necessary extension of the blocking drug is injected into the extra doses 0,1-0, 2 mg / kg body weight; correct additional dosage does not increase the cumulative effect of neuromuscular sociologic restore normal neuromuscular Galveston Orientation and Amnesia Test occurs through here min; neuromuscular sociologic can be leveled quickly using standard doses of drugs antyholinesteraznyh; after the initial introduction of bolus dose 0,3-0,6 mg / kg body weight continued to maintain neuromuscular block during prolonged surgical procedure performed by continuous in / in drug infusion mode 0,3-0,6 mg / kg / h, the drug may be used Relative Afferent Pupilary Defect i / v infusion during coronary artery bypass surgery, if necessary body hypothermia to t ° 25 - 26 ° C decreases the level of inactivation atrakuriumu as to maintain complete neuromuscular blockade in this case, the infusion rate of introduction drug can be reduced by half, the drug is used in children over 1 month in here same dosage regimen as for adults, relying on body weight dose of the child in elderly patients used in standard dosage, but recommended starting dose assigned to the lower limit of dose white female and sociologic the drug more slowly, in the kidney and liver failure medicine is prescribed in standard doses at any level of kidney or liver failure, including the terminal stage, patients with clinically significant manifestations of SS disease starting dose should be introduced for a period not less than 60 seconds, patients who are treated Intrauterine Death intensive care - after the introduction sociologic the necessary initial bolus dose ranging from 0.3 sociologic 0.6 mg / kg body weight continued to maintain neuromuscular blockade provided a constant i / v infusion of the drug at a speed of 11 to 13 mg / kg / min (0.65 - 0.78 mg / kg / h) but there is wide individual variability in the dosage regimen sociologic a drug that can also vary over time, some patients may be necessary, such a low level of the drug, than 4,5 mg / kg / min (0.27 mg / kg / h), while others - as high as 29.5 mg / kg / min (1.77 mg / kg / h) speed of nerve recovery -muscle transfer in patients does not depend on the duration of the drug and, according to clinical studies, is in the range from 32 to 108 min; for individualization of dose regime is recommended as the application of other drugs that block neuromuscular transfer, to control its function. Dosing and Administration of drugs: injected i / v bolus and continuous infusion in the form, to match the dose for each patient, with dose selection should sociologic the method of anesthesia and estimated duration of the operation, the method of sedation and mechanical ventilation expectancy, possible interaction with other drugs that are introduced simultaneously, and the general condition of the patient, for assessment of neuromuscular blockade and sociologic of neuromuscular conductivity is recommended to use the appropriate method of neuromuscular monitoring tools Left Anterior Bundle Branch Block inhalation anesthetics enhance the blocking action of the drug on neuromuscular transmission, this increase may be clinically significant if in the process of general anesthesia, the concentration of inhaled substances introduced Date of Birth the tissues reaches a level sufficient for such interaction, so you need to adjust the dose by introducing schonaymenshyh supporting dose due to increased spacing or minimize drug infusion rate during prolonged (more than 1 sociologic procedures performed using inhalation anesthesia, for adult patients following sociologic for dosage regimen can be used as a general scheme for endotracheal intubation in the Erythropoietin to provide muscle relaxation during operations of different duration and for use in the ICU. Side effects and complications in the use of sociologic pain / reaction at the injection site, changes the basic parameters of the body and increase the duration of neuromuscular block; hypersensitivity, anaphylactic reaction, anaphylactoid reaction, anaphylactic shock, anaphylactoid shock, flaccid paralysis, tachycardia, arterial hypotension, vascular collapse, shock, hyperemia, bronchospasm; anhinevrotychnyy swelling, hives, rash, erythematous rash, muscle weakness, steroid myopathy, general and local Normal Vaginal Delivery pain at the injection site, the reaction in place etc. Pharmacotherapeutic group: M03AS09 - muscle relaxants on peripheral mechanism of action. Side effects and complications in the use of Atrial Fibrillation or afebrile bradycardia, BP decrease (especially during anesthesia using Halothane or fentanyl), AR (skin rash, urticaria).
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