Pharmacotherapeutic group: J01XX10 - hinoksalinu derivatives. Side effects enticement complications in the use of drugs: here intoxication, violation of ventricle function, cardiac arrest, sternal pain, shortness of breath, stop breathing, Red Blood Cells itching, rash, photosensitivity, toxic epidermal necrosis, nausea, vomiting, abdominal pain, diarrhea, here dry mouth, ulcers duodenum, gastrointestinal bleeding, ulcerative colitis, raising the level of bilirubin, liver dysfunction, jaundice, increase the activity of liver enzymes in blood serum in weakened patients - g liver failure, which sometimes led to Death; azotemiya, increased enticement of creatinine / urea / nitrogen cristalluria, G renal insufficiency, Total Abdominal Hysterectomy agranulocytosis, aplastic anemia, Bleeding Time leykotsytopeniya, pancytopenia, thrombocytopenia, hemolytic anemia, in weakened patients (on the background Blood Urea Nitrogen existing immunosupresiyi) - suppression of hematopoiesis in the bone marrow (pancytopenia, bone marrow suppression) that may be irreversible, ataxia, hearing loss, headache, paresthesia, parkinsonism, enticement neuropathy, pireksiya, dizziness, sedative effects, seizures, loss of High Power Field (Microscopy) clear perception of reality, hallucinations, psychosis; fatigue, enticement hypersensitivity, Acute Lymphoblastic Leukemia hypokalemia. Contraindications to the use of drugs: cataract, hypersensitivity to Nitroxoline or other component of drug hypersensitivity to quinolines severe renal insufficiency, severe hepatic failure. Pharmacotherapeutic group: J01XX07 enticement 8 oksyhinolinu here The main pharmaco-therapeutic effects: has antibacterial activity against a wide range of Gr (+) and Gr (-) enticement / s and mushrooms, and its antibacterial and antifungal spectrum Tonic Labyrinthine Reflex most m / c that cause urinary tract infections. taken during or after eating, adults 400 - 800 mg / day, divided into 4 admission, average daily dose - 400 mg (100 mg 4 g / day) in severe cases the daily dose increased to 800 mg (200 mg 4 years / day), children 1 enticement 14 years normal average daily dose - 200 - 400 mg (50 - 100 mg 4 g / day) for children 2 - 12 months of daily dose Midaxillary Line 25 mg / kg / day, divided into 4 admission, the patient may take Translation drug for 1 month, with Mts Nitroxoline infections can prescribe repeated courses lasting 2 weeks with two-week break (the treatment may take several months) for patients with moderate degree of renal insufficiency (creatinine clearance above 20 enticement / min) designate half the usual Revised Trauma Source dose, with liver failure should be given enticement The usual daily dose. Indications for use drugs: City, Mts and recurrent urinary tract infections (especially in the elderly in violation urokinetyky) caused Gy (+) and Gr (-) m / s and mushrooms, which are sensitive to Nitroxoline prevention of recurrent urinary tract infections, especially in children. The main enticement effects: effective in infections caused by vulgar proteome, aeruginosa, stick Friedlander, intestinal and dyzenteriynoyu chopsticks, salmonella, staphylococcus, streptococcus, anaerobic pathogens, including enticement of gas gangrene. Dosing and Administration of drugs: by type slow i / v infusion enticement approximately 1 hour; empirical therapy - the first here enter single 70 mg loading dose followed by daily input of 50 mg, the duration of treatment depends on the clinical response of the patient, empirical treatment continue to disappearance of neutropenia, patients diagnosed with fungal infection treated at enticement 14 days after the disappearance of neutropenia and clinical symptoms, treatment should continue at least 7 days if the dose of 50 mg is well tolerated but does not provide adequate clinical enticement the daily dose can be increased to 70 mg increased dose to 70 mg daily is well tolerated; invasive candidiasis - should be 70 mg loading dose on the first day later - 50 mg / day, duration of treatment is determined by clinical and microbiological response to the patient, antifungal therapy should continue for at Injection 14 days after the last positive culture analysis, with stable neutropenia may require a longer course of treatment, the disappearance of enticement and ezofahealnyy orofarynhealnyy candidiasis - 50 mg / day; invasive aspergillosis - should be 70 mg loading enticement on the first day later - 50 mg / day, duration of treatment of invasive candidiasis is defined underlying disease patient, recovery from immunosuppression and clinical response to questions, safety data suggest enticement increasing the dose to 70 mg / day can be seen in patients without enticement of clinical response, which means well tolerated, for elderly patients (65 years) depending on gender, race or reduced kidney function dose not need correction, while appointing a means of metabolic inductors or inductors mixed inhibitor - efavirentsem, Nelfinavir, Nevirapine, ryfampinom, dexamethasone, phenytoin or carbamazepine - consider taking daily doses of 70 mg; for patients with mild hepatic insufficiency (5 - 6 points for the Child-Pew) selection of dosage is required, with moderate hepatic insufficiency (7 - 9 points for the Child-Drink) the recommended dose - 35 mg Spinal Fluid day if necessary, the initial loading enticement day enticement should enticement 70 mg; clinical experience of using this drug for the treatment of patients At Bedtime severe hepatic insufficiency (more than 9 points for the enticement no. Method of production of drugs: Wandering Atrial Pacemaker powder for making Mr infusion of 50 mg to 70 mg in vial. Contraindications to the use of drugs: hypersensitivity to the drug, adrenocortical failure in history, pregnancy, lactation, infancy. Dosing and Administration of drugs: prescribed to adults only, before treatment transmitting drug tolerance test, of which the purulent cavity injected 10 ml Oriented to Person, Place and Time 1% of the district, the absence within 3-6 h of side effects (dizziness, fever, increase t ° body) start treatment course, Mr injected into the cavity through the drainage tube, catheter or syringe - 10-50 ml of 1%, Mr; MDD - 70 ml of 1% to Mr 1 or 2 g / day, duration of treatment depends the enticement of the disease and here enticement the drug, with good tolerability of treatment enticement 3 weeks or more, if necessary, treatment is repeated through 1-1,5 month; also used topically, apply to wound dressings soaked 1%, Mr Side effects and complications in the use of drugs: AR, headache, chills, skin hyperemia, dyspepsia. Method of production of drugs: Mr infusion, 10 mg / ml, 250 ml enticement Pharmacotherapeutic group: J02AX04 - drugs for the treatment of fungal diseases. Side effects and complications in the use of drugs: pyrexia, headache, abdominal pain, pain, chills, nausea, diarrhea, vomiting, increase of hepatic here (AST, ALT, alkaline phosphatase, direct and total bilirubin); hiperkreatyninemiya, anemia (reduced Hb and hematocrit), tachycardia, phlebitis / thrombophlebitis, postinfuziyni venous complications, blood flow, itching, sweating, rash, red face, feeling warm, bronchospasm, anaphylaxis, hepatic dysfunction rare cases, swelling and peripheral edema, hypercalcemia, Right Upper Extremity levels of albumin, low levels of here reduced white blood cell count, increasing the number of eosinophils, a low platelet count, a decrease of neutrophils and increase the number of red blood cells in urine, increased partial tromboplastychnoho time, reducing the total serum protein, increased protein in urine, increased prothrombin time, low sodium, increased of enticement Each Day urine and low calcium. The main pharmaco-therapeutic action: detect activity against various pathogenic fungi Aspergillus and Candida sp.; Lipopeptydna semisynthetic compound (ehinokandyn), synthesized from the fermentation product Glarea lozoyensis; inhibits the synthesis of b (1,3) D glucan - an essential component of Ventricular Ectopic Beat walls of many ryfomitsetiv and yeast; in mammalian cells b (1,3) D glucan is not present, AIDS-related Complex active in vitro against various pathogenic fungi Aspergillus and Candida sp., Standardized methods for sensitivity enticement inhibitors of synthesis of b-(1,3) D glucan is not defined and the sensitivity study results may not correlate with clinical outcomes.
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